Genetically determined angiotensin converting enzyme level and myocardial tolerance to ischemia

Angiotensin Converting Enzyme in Sarcoidosis

Plasma level and gene polymorphism of angiotensin-converting enzyme in relation to myocardial infarction.

BACKGROUND The angiotensin-converting enzyme (ACE) plays an important role in the production of angiotensin II and the degradation of bradykinin, two peptides involved in cardiovascular homeostasy. Presence of a polymorphism in the ACE gene (ACE Ss) has been postulated from segregation analysis of plasma ACE in families. This putative polymorphism, which strongly affects the plasma and cellular...

Genetically increased angiotensin I-converting enzyme level and renal complications in the diabetic mouse.

Diabetic nephropathy is a major risk factor for end-stage renal disease and cardiovascular diseases and has a marked genetic component. A common variant (D allele) of the angiotensin I-converting enzyme (ACE) gene, determining higher enzyme levels, has been associated with diabetic nephropathy. To address causality underlying this association, we induced diabetes in mice having one, two, or thr...

angiotensin converting enzyme in sarcoidosis

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Is there a role for angiotensin-converting enzyme inhibitors in the treatment of chronic myocardial ischemia?